A rapid, specific and economic UV spectrophotometric method has been developed using Methanol as a solvent to determine the simvastatin and ezetimibe content in bulk and pharmaceutical dosage formulations at a pre-determined λmax of Simvastatin and Ezetimibe 249 nm and 228 nm respectively, it was proved linear in the range of 2.0–10.0 µg/mL, and exhibited good correlation coefficient (R²=0.999 for Simvastatin and R²=0.998 for Ezetimibe) and excellent mean recovery (99.65–99.98 % for Simvastatin and 98.23-99.11 % for ezetimibe). This method was successfully applied to the determination of simvastatin and ezetimibe content in marketed brands and the results were in good agreement with the label claims. The method was validated statistically and by recovery studies for linearity, precision, repeatability, and reproducibility. The obtained results proved that the method can be employed for the routine analysis of simvastatin and ezetimibe in bulks as well as in the commercial formulations.