There is evident from the concerned literature that since ancient period herbal, animal origin, mineral and herbo-mineral preparations were found to used for prolong period of life span and to maintain health. Nagarjuna, an indian alchemist (8^th cent.A.D.) flourished alchemy in india. Most of the Ancient author’s were recommended purified and processed metals, minerals and gems in the treatment, because of its fast acting, low dose, no self-life etc. Mercury (Parada) is the most important drug, has a special importance in Indian alchemy (Rasashastra) than other components. It has the ability and power to assimilate all the drugs (such as Dhatu, Upadhatu, etc). It works very effective and increases its potency when it processed and purified with special procedures (Samskara). The important minerals are classified into maha (superior) rasa and Upa (subsidiary) rasa, Sadarana rasa etc. Indian alchemy literature was given the processes and purification methods (Sodhana) of metals, minerals and gems, dose fixation, indication and adverse effects if it used in impure form, vehicle of specific drug etc.