In the present study, the antiobesity potential of Rumex nervosus Vahl leaves was studied against high fat diet-induced obesity in female rats. In this study, administration of high fat diet in rats produced hyperglycemia and hyperlipidemia, which led to an increase in the body weight compared to control rats. In high fat diet, treated rats with the Rumex nervosus Vahl leaves powdered mixed with the diet at 10% of the diet reduced the body weight and produced signs of recovery in body weights to the level of normal control group. Treatment of high fat diet rats with Rumex nervosus Vahl leaves powdered did not appaerencally effect rats food or water intake through the 8 weeks of the treatment. After 8 weeks of treatment, the high fat diet that received Rumex nervosus Vahl had lower blood glucose concentrations compared with high fat diet group. At week, 8 of treatment plasma triglycerides and low density lipoprotein cholesterol levels of high fat diet treated rats were lower compared to high fat diet group. On the other hand, no significant changes in plasma high-density lipoprotein cholesterol in treated groups compared to high fat diet group at week 8. Administration of Rumex nervosus Vahl leaves powdered to high fat diet rats caused reversal of the elevations in alanine aminotransferase and Gamma-glutamyl transferase that were elicited by high fat diet and the values were nearly to the levels shown by normal control group. Creatinine levels were not affected by high fat diet nor by the treatment. Urea levels were significantly higher in high fat diet group compared to normal control group. In conclusion it is illustrated that the Rumex nervosus Vahl leaves powdered showed prevention effect on high fat diet-induced hyperglycemia and hyperlipidemia in female Albino rats thus, its prevent effect without showing any toxic effect.