Group II and group IV male rats showed prominent clinical signs such as increased salivation, piloerection, lethargy, increased urine output, diarrhoea and hair loss (from 14^th day onward), Body weight (from 14^th day onward) and Relative organ weights at 28^th day interval were significantly decreased in a rats of group II and IV. No appreciable gross changes were recorded in organs, except, there was focal areas of necrosis and mild to moderate congestion in liver of rats of group II and IV. Histologically, alterations recorded were haemorrhages, degenerative and necrotic changes in Liver and Kidney sections; marked depopulation of lymphocytes in spleen; catarrhal enteritis with MNC infiltration in Intestines; depopulation of spermatogonial cells with emptying of seminiferous tubules in Testes; degenerative and necrotic changes in neurons with vacuolations in parenchyma of Brain. These appreciable changes showed improvement due to S. chirata.