ARCHIVES
VOL. 9, ISSUE 2 (2025)
Synthesis and antibacterial activity of 2,9-(disubstituted)-6,13-dimethoxy-5,12-dihydroquinoxalino [2,3-b] phenazine Derivatives
Authors
CH Sudhakar
Abstract
A novel series of
2,9-(disubstituted)-6,13-dimethoxy-5,12-dihydroquinoxalino [2,3-b] phenazine
derivatives 3(a–d) was successfully synthesized with moderate yields (52–61%).
The structures of these newly developed nitrogen-fused heterocyclic frameworks
were confirmed via FT-IR, 1H-NMR, 13C-NMR, ESI-MS and
elemental analysis. All synthesized target molecules were evaluated in vitro
for their antibacterial efficacy against Gram-positive Staphylococcus aureus,
Micrococcus luteus, Bacillus subtilis and Gram-negative Escherichia
coli, Salmonella paratyphi, Klebsiella pneumoniae bacterial
strains using the disk diffusion technique. Among the series, compounds 3b
(chloro-substituted) and 3c (bromo-substituted) demonstrated moderate
antibacterial activity, producing zones of inhibition (15–19 mm) compared to
the commercial standard drug, Streptomycin. This study highlights the
therapeutic potential of modified phenazine-quinoxaline hybrids as
next-generation antibacterial scaffolds.
Download
Pages:101-104
How to cite this article:
CH Sudhakar "Synthesis and antibacterial activity of 2,9-(disubstituted)-6,13-dimethoxy-5,12-dihydroquinoxalino [2,3-<i>b</i>] phenazine Derivatives". International Journal of Chemical Science, Vol 9, Issue 2, 2025, Pages 101-104
Download Author Certificate
Please enter the email address corresponding to this article submission to download your certificate.